The time lapse movie (originally 13-hours-lating) shows in vitro model of the therapy with CARTREGS manufactured in Poltreg’s laboratory. The big cell in the middle express cloned glia antigens. It is actively recognised by the manufactured CARTREGS (small green cells) expressing CAR receptors towards the antigens. The CARTREGS attach to the surface of glia cell and actively protect it against autoimmune attack.

Poltreg S.A. develops CARTREG cell therapy product in the cooperation with AZTherapies from Boston, USA. The therapy with the cells will be tried in clinical trials in neuroimmune conditions such as amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS). CARTREGS are engineered T regulatory cells expressing chimeric receptor cloned into the cells. Poltreg’s product contains receptors against glia. This design allows CARTREGS for the recognition of glia of the brain and spinal cord, where they generate functional barrier and protect the central nervous system against autoimmune attack. This way the disease can be alleviated or even stopped.

More details about the technology will be presented at the conference ‘Therapeutic Tolerance Lessons Learned’ organized by the University Newcastle in Newcastle upon Tyne, UK, 28th June -1st July 2022

Movie by Magdalena Piotrowska, Mateusz Gliwiński, Aurelia Schweda and Dorota Iwaszkiewicz-Grześ.